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Oral metronidazole has become noted to potentiate the anticoagulant effect of coumarin and warfarin, causing a prolongation of prothrombin time. Use caution when prescribing for sufferers that are receiving anticoagulant therapy.

The pharmacodynamics of metronidazole in association Using the procedure of rosacea are unknown. Cardiac Electrophysiology: The impact of METROGEL within the QTc interval has not been sufficiently characterized.

The subsequent adverse reaction has been recognized all through write-up-acceptance usage of topical metronidazole. Simply because this reaction is documented voluntarily from a inhabitants of uncertain size, It is far from usually feasible to reliably estimate the frequency or create a causal connection to drug publicity.

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Irritant and allergic Get in touch with dermatitis are already documented with METROGEL. If dermatitis occurs, people might require to discontinue use.

Oral metronidazole has become documented to potentiate the anticoagulant influence of coumarin and warfarin, resulting in a prolongation of prothrombin time.

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Oral metronidazole has become claimed to potentiate the anticoagulant influence of coumarin jnetoto and warfarin, leading to a prolongation of prothrombin time. Use warning when administering METROGEL concomitantly to clients who are obtaining anticoagulant treatment. (seven)

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